Assay Detail
Binding
CHEMBL884411
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potassium channel opening activity in vitro using LtK cells transfected with Kir6.2/SUR2B exon 17
51
Total Activities
51
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Cell Type | LtK |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
ATP-sensitive inward rectifier potassium channel 11 (CHEMBL1886) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 51 | 6.76 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL48848 | — | — | 1 | 8.05 |
| CHEMBL49806 | — | — | 1 | 7.92 |
| CHEMBL50374 | — | — | 1 | 7.92 |
| CHEMBL50760 | — | — | 1 | 7.82 |
| CHEMBL299167 | — | — | 1 | 7.75 |
| CHEMBL300958 | — | — | 1 | 7.64 |
| CHEMBL48797 | — | — | 1 | 7.62 |
| CHEMBL49787 | — | — | 1 | 7.36 |
| CHEMBL51071 | — | — | 1 | 7.36 |
| CHEMBL47170 | — | — | 1 | 7.35 |
| CHEMBL300969 | — | — | 1 | 7.34 |
| CHEMBL298866 | — | — | 1 | 7.33 |
| CHEMBL49116 | — | — | 1 | 7.31 |
| CHEMBL49076 | — | — | 1 | 7.22 |
| CHEMBL48291 | — | — | 1 | 7.16 |
| CHEMBL49153 | — | — | 1 | 7.14 |
| CHEMBL296954 | — | — | 1 | 7.12 |
| CHEMBL298383 | — | — | 1 | 7.10 |
| CHEMBL45937 | — | — | 1 | 7.09 |
| CHEMBL298970 | — | — | 1 | 7.08 |
| CHEMBL301296 | — | — | 1 | 7.01 |
| CHEMBL295458 | — | — | 1 | 6.93 |
| CHEMBL49797 | — | — | 1 | 6.88 |
| CHEMBL49701 | — | — | 1 | 6.86 |
| CHEMBL51460 | — | — | 1 | 6.81 |
| CHEMBL48801 | — | — | 1 | 6.80 |
| CHEMBL48765 | — | — | 1 | 6.73 |
| CHEMBL46244 | — | — | 1 | 6.71 |
| CHEMBL45749 | — | — | 1 | 6.67 |
| CHEMBL48174 | — | — | 1 | 6.56 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL48848 | — | EC50 | = | 9.0 | nM | 8.05 |
| CHEMBL49806 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL50374 | — | EC50 | = | 12.0 | nM | 7.92 |
| CHEMBL50760 | — | EC50 | = | 15.0 | nM | 7.82 |
| CHEMBL299167 | — | EC50 | = | 18.0 | nM | 7.75 |
| CHEMBL300958 | — | EC50 | = | 23.0 | nM | 7.64 |
| CHEMBL48797 | — | EC50 | = | 24.0 | nM | 7.62 |
| CHEMBL49787 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL51071 | — | EC50 | = | 44.0 | nM | 7.36 |
| CHEMBL47170 | — | EC50 | = | 45.0 | nM | 7.35 |
| CHEMBL300969 | — | EC50 | = | 46.0 | nM | 7.34 |
| CHEMBL298866 | — | EC50 | = | 47.0 | nM | 7.33 |
| CHEMBL49116 | — | EC50 | = | 49.0 | nM | 7.31 |
| CHEMBL49076 | — | EC50 | = | 60.0 | nM | 7.22 |
| CHEMBL48291 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL49153 | — | EC50 | = | 72.0 | nM | 7.14 |
| CHEMBL296954 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL298383 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL45937 | — | EC50 | = | 81.0 | nM | 7.09 |
| CHEMBL298970 | — | EC50 | = | 84.0 | nM | 7.08 |
| CHEMBL301296 | — | EC50 | = | 98.0 | nM | 7.01 |
| CHEMBL295458 | — | EC50 | = | 117.0 | nM | 6.93 |
| CHEMBL49797 | — | EC50 | = | 131.0 | nM | 6.88 |
| CHEMBL49701 | — | EC50 | = | 137.0 | nM | 6.86 |
| CHEMBL51460 | — | EC50 | = | 154.0 | nM | 6.81 |
| CHEMBL48801 | — | EC50 | = | 160.0 | nM | 6.80 |
| CHEMBL48765 | — | EC50 | = | 185.0 | nM | 6.73 |
| CHEMBL46244 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL45749 | — | EC50 | = | 213.0 | nM | 6.67 |
| CHEMBL48174 | — | EC50 | = | 276.0 | nM | 6.56 |
| CHEMBL49348 | — | EC50 | = | 306.0 | nM | 6.51 |
| CHEMBL301591 | — | EC50 | = | 317.0 | nM | 6.50 |
| CHEMBL48615 | — | EC50 | = | 417.0 | nM | 6.38 |
| CHEMBL49191 | — | EC50 | = | 495.0 | nM | 6.30 |
| CHEMBL296931 | — | EC50 | = | 570.0 | nM | 6.24 |
| CHEMBL296840 | — | EC50 | = | 751.0 | nM | 6.12 |
| CHEMBL45645 | — | EC50 | = | 1160.0 | nM | 5.94 |
| CHEMBL48755 | — | EC50 | = | 1750.0 | nM | 5.76 |
| CHEMBL49551 | — | EC50 | = | 2040.0 | nM | 5.69 |
| CHEMBL49321 | — | EC50 | = | 2220.0 | nM | 5.65 |
| CHEMBL299166 | — | EC50 | = | 4340.0 | nM | 5.36 |
| CHEMBL48890 | — | EC50 | = | 4840.0 | nM | 5.32 |
| CHEMBL50501 | — | EC50 | = | 5310.0 | nM | 5.28 |
| CHEMBL46435 | — | EC50 | = | 5550.0 | nM | 5.26 |
| CHEMBL49070 | — | EC50 | = | 6630.0 | nM | 5.18 |
| CHEMBL296879 | — | EC50 | = | 177000.0 | nM | - |
| CHEMBL46245 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL49549 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL47061 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL52283 | — | EC50 | > | 10000.0 | nM | - |