Compound Detail
CHEMBL301296
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Basic Information
| ChEMBL ID | CHEMBL301296 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VMKJKSGGERWXIK-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
447.8
MW (Da)
6.06
ALogP
2
HBA
2
HBD
49.3
PSA (Ų)
0.48
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.01
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 11 CHEMBL1886 | EC50 | 7.01 | 7.01 | 98.0 | 1 |
| Sulfonylurea receptors; K-ATP channels CHEMBL2095152 | EC50 | 6.07 | 6.07 | 851.1 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| ATP-sensitive inward rectifier potassium channel 11 | EC50 | = | 98.0 | nM | 7.01 | Potassium channel opening activity in vitro using LtK cells transfected with Kir... | 12729655 |
| Sulfonylurea receptors; K-ATP channels | EC50 | = | 851.14 | nM | 6.07 | Potent effective concentration was evaluated for KATP channel opening activity i... | 12729655 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12729655 | 10.1016/s0960-894x(03)00205-1 | Sulfonylurea receptors; K-ATP channels | 2 |
| 12729655 | 10.1016/s0960-894x(03)00205-1 | ATP-sensitive inward rectifier potassium channel 11 | 1 |
Data from ChEMBL 36 via Core Engine