Assay Detail
Functional
CHEMBL762563
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Potent effective concentration was evaluated for KATP channel opening activity in pig bladder strips
17
Total Activities
17
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Sus scrofa |
| Confidence | 4 — Cell-line / Tissue |
| Curated By | Autocuration |
Target
Sulfonylurea receptors; K-ATP channels (CHEMBL2095152) ↗| Type | PROTEIN COMPLEX GROUP |
| Organism | Homo sapiens |
Publication
Structure-activity relationship of a novel class of naphthyl amide KATP channel openers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 17 | 6.70 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL50760 | — | — | 1 | 8.05 |
| CHEMBL49153 | — | — | 1 | 7.31 |
| CHEMBL300958 | — | — | 1 | 7.28 |
| CHEMBL47170 | — | — | 1 | 7.09 |
| CHEMBL299167 | — | — | 1 | 7.02 |
| CHEMBL296840 | — | — | 1 | 6.90 |
| CHEMBL48848 | — | — | 1 | 6.74 |
| CHEMBL45749 | — | — | 1 | 6.69 |
| CHEMBL48797 | — | — | 1 | 6.52 |
| CHEMBL49806 | — | — | 1 | 6.43 |
| CHEMBL296931 | — | — | 1 | 6.41 |
| CHEMBL295458 | — | — | 1 | 6.37 |
| CHEMBL49035 | CROMAKALIM | 2.0 | 1 | 6.34 |
| CHEMBL300969 | — | — | 1 | 6.26 |
| CHEMBL49076 | — | — | 1 | 6.21 |
| CHEMBL49797 | — | — | 1 | 6.15 |
| CHEMBL301296 | — | — | 1 | 6.07 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL50760 | — | EC50 | = | 8.913 | nM | 8.05 |
| CHEMBL49153 | — | EC50 | = | 48.98 | nM | 7.31 |
| CHEMBL300958 | — | EC50 | = | 52.48 | nM | 7.28 |
| CHEMBL47170 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL299167 | — | EC50 | = | 95.5 | nM | 7.02 |
| CHEMBL296840 | — | EC50 | = | 125.89 | nM | 6.90 |
| CHEMBL48848 | — | EC50 | = | 181.97 | nM | 6.74 |
| CHEMBL45749 | — | EC50 | = | 204.17 | nM | 6.69 |
| CHEMBL48797 | — | EC50 | = | 302.0 | nM | 6.52 |
| CHEMBL49806 | — | EC50 | = | 371.54 | nM | 6.43 |
| CHEMBL296931 | — | EC50 | = | 389.05 | nM | 6.41 |
| CHEMBL295458 | — | EC50 | = | 426.58 | nM | 6.37 |
| CHEMBL49035 | CROMAKALIM | EC50 | = | 457.09 | nM | 6.34 |
| CHEMBL300969 | — | EC50 | = | 549.54 | nM | 6.26 |
| CHEMBL49076 | — | EC50 | = | 616.6 | nM | 6.21 |
| CHEMBL49797 | — | EC50 | = | 707.95 | nM | 6.15 |
| CHEMBL301296 | — | EC50 | = | 851.14 | nM | 6.07 |