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Compound Detail

CHEMBL4643867

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O=C(Nc1ccc(F)cc1-c1ccc(Cl)c(Cl)c1)O[C@H]1CN2CCC1CC2

Basic Information

ChEMBL ID CHEMBL4643867
Phase Preclinical
Structure Type MOL
InChI Key LVPIEYVPDBYBIT-IBGZPJMESA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
5
Publications
0
Known Names

Molecular Properties

409.3
MW (Da)
5.44
ALogP
3
HBA
1
HBD
41.6
PSA (Ų)
0.73
QED
1
Ro5 Violations
3
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H19Cl2FN2O2
MW 409.29
Aromatic Rings 2
Heavy Atoms 27
NP-Likeness -0.85

Activity Summary

Ki 3 meas. best 9.28

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Muscarinic acetylcholine receptor M3
CHEMBL245
Ki 9.28 9.28 0.5 1
Muscarinic acetylcholine receptor M1
CHEMBL216
Ki 9.14 9.14 0.7 1
Muscarinic acetylcholine receptor M2
CHEMBL211
Ki 7.89 7.89 13.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32202101 10.1021/acs.jmedchem.0c00297 Muscarinic acetylcholine receptor M1 1
32202101 10.1021/acs.jmedchem.0c00297 Muscarinic acetylcholine receptor M2 1
32202101 10.1021/acs.jmedchem.0c00297 Muscarinic acetylcholine receptor M3 1
32202101 10.1021/acs.jmedchem.0c00297 Muscarinic acetylcholine receptor M1 and M3 1
32202101 10.1021/acs.jmedchem.0c00297 Muscarinic acetylcholine receptors; M2 & M3 1

Data from ChEMBL 36 via Core Engine