Compound Detail
CHEMBL464966
IZALPININ Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL464966 |
| Name | IZALPININ |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PVJNLMXWZXXHSZ-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
284.3
MW (Da)
2.88
ALogP
5
HBA
2
HBD
79.9
PSA (Ų)
0.76
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 4.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| NON-PROTEIN TARGET CHEMBL3879801 | EC50 | 4.52 | 4.52 | 30300.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| NON-PROTEIN TARGET | EC50 | = | 30300.0 | nM | 4.52 | Antiproliferative activity against mouse 26-L5 cells after 72 hrs by MTT assay | 12027739 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 12398545 | 10.1021/np020078o | Macrophage | 5 |
| 12398545 | 10.1021/np020078o | RBL-2H3 | 3 |
| 12027739 | 10.1021/np010486c | NON-PROTEIN TARGET | 2 |
| 12398545 | 10.1021/np020078o | ADMET | 1 |
| 12027739 | 10.1021/np010486c | HT-1080 | 1 |
| 12027739 | 10.1021/np010486c | A549 | 1 |
| 12027739 | 10.1021/np010486c | HeLa | 1 |
| 20307087 | 10.1021/np900772m | PANC-1 | 1 |
| 23134335 | 10.1021/np300660y | KB | 1 |
Data from ChEMBL 36 via Core Engine