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Compound Detail

CHEMBL4650226

ACORAMIDIS HYDROCHLORIDE
💊 Approved Drug
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💊 Approved Drug
Cc1n[nH]c(C)c1CCCOc1cc(C(=O)O)ccc1F.Cl
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4650226
Name ACORAMIDIS HYDROCHLORIDE
Phase Approved
Structure Type MOL
InChI Key MGFZEARHINUOMX-UHFFFAOYSA-N
Therapeutic ✓ Yes
Parent Compound CHEMBL3940890
Active Moiety CHEMBL3940890

Known Names

Acoramidis hydrochloride AG-10 HYDROCHLORIDE AG10 hydrochloride Alxn-2060 hydrochloride Alxn2060 hydrochloride Attruby
0
Targets
0
Activities
0
Assay Types
0
PK Parameters
0
Publications
6
Known Names
3
Indications
1
Mechanisms

Molecular Properties

292.3
MW (Da)
2.88
ALogP
3
HBA
2
HBD
75.2
PSA (Ų)
0.80
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
First Approval 2024
Availability Prescription
Chirality Achiral

Routes of Administration

Oral
USAN Stem -amidis
USAN Year 2020

Extended Properties

Molecular Formula C15H18ClFN2O3
MW 328.77
Aromatic Rings 2
Heavy Atoms 21
NP-Likeness -1.34

Mechanism of Action

Mechanism Action Type Target Direct Efficacy
Transthyretin stabiliser STABILISER Transthyretin ✓ ✓

Indications

Amyloidosis Amyloidosis Cardiomyopathies

Data from ChEMBL 36 via Core Engine