Compound Detail
CHEMBL465767
HYRTIOSULAWESINE Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL465767 |
| Name | HYRTIOSULAWESINE |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | OATSYJQLKPRTBO-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
343.3
MW (Da)
3.84
ALogP
4
HBA
4
HBD
102.0
PSA (Ų)
0.37
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.89 | 5.89 | 1300.0 | 1 |
| Phospholipase A2 alpha CHEMBL5711 | IC50 | 4.85 | 4.85 | 14000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 1300.0 | nM | 5.89 | Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 a... | 36931118 |
| Phospholipase A2 alpha | IC50 | = | 14000.0 | nM | 4.85 | Inhibition of Crotalus adamanteus venom phospholipase A2 by fluorometric assay | 17190441 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17190441 | 10.1021/np060132r | Phospholipase A2 alpha | 1 |
| 36931118 | 10.1016/j.ejmech.2023.115247 | Plasmodium falciparum | 1 |
Data from ChEMBL 36 via Core Engine