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Compound Detail

CHEMBL468382

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Cc1ccc2c(O)c(C(=O)NCCCNC(=O)c3ccc4nc(C)ccc4c3O)ccc2n1

Basic Information

ChEMBL ID CHEMBL468382
Phase Preclinical
Structure Type MOL
InChI Key ZXOFUGNADSLZBM-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

444.5
MW (Da)
3.36
ALogP
6
HBA
4
HBD
124.4
PSA (Ų)
0.34
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C25H24N4O4
MW 444.49
Aromatic Rings 4
Heavy Atoms 33
NP-Likeness -0.51

Activity Summary

IC50 2 meas. best 4.71

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Chlorella vulgaris
CHEMBL613342
IC50 4.71 4.71 19500.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Chlorella vulgaris IC50 = 19500.0 nM 4.71 Herbicidal activity against Chlorella vulgaris Beij assessed as decrease in chlo... 18342517

Literature References

PubMed DOI Target Context # Activities
18342517 10.1016/j.bmc.2008.02.065 No relevant target 1
18342517 10.1016/j.bmc.2008.02.065 Spinacia oleracea 1
18342517 10.1016/j.bmc.2008.02.065 Chlorella vulgaris 1

Data from ChEMBL 36 via Core Engine