Compound Detail
CHEMBL469055
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Basic Information
| ChEMBL ID | CHEMBL469055 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QBSQJJUIEKBBLE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
322.4
MW (Da)
4.61
ALogP
4
HBA
0
HBD
43.1
PSA (Ų)
0.48
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.12
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Bone morphogenetic protein 4 CHEMBL5350 | IC50 | 6.12 | 6.12 | 750.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Bone morphogenetic protein 4 | IC50 | = | 750.0 | nM | 6.12 | Inhibition of BMP4-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular EL... | 18621530 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18621530 | 10.1016/j.bmcl.2008.06.052 | Bone morphogenetic protein 4 | 1 |
Data from ChEMBL 36 via Core Engine