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Assay Detail

CHEMBL989154

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Inhibition of BMP4-induced phosphorylation of SMAD 1/5/8 by cytoblot cellular ELISA
30
Total Activities
30
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Confidence 8 — Homologous single protein target
Curated By Intermediate

Target

Bone morphogenetic protein 4 (CHEMBL5350)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors.
Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT.
Bioorg Med Chem Lett (2008) 18 : 4388 -4392
PubMed 18621530 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 30 6.34 8.31

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL513147 1 8.31
CHEMBL467972 1 8.30
CHEMBL469053 1 8.00
CHEMBL511563 1 7.26
CHEMBL469054 1 7.05
CHEMBL467560 1 6.82
CHEMBL467345 1 6.60
CHEMBL468399 1 6.46
CHEMBL478629 DORSOMORPHIN 1 6.37
CHEMBL466765 1 6.35
CHEMBL511929 1 6.30
CHEMBL511216 1 6.30
CHEMBL469055 1 6.12
CHEMBL324153 1 5.70
CHEMBL467544 1 5.58
CHEMBL502351 1 5.52
CHEMBL468003 1 5.48
CHEMBL469019 1 5.35
CHEMBL512294 1 5.30
CHEMBL329350 1 5.19
CHEMBL468216 1 4.70
CHEMBL468853 1 -
CHEMBL466953 1 -
CHEMBL467543 1 -
CHEMBL469259 1 -
CHEMBL454786 1 -
CHEMBL467142 1 -
CHEMBL513333 1 -
CHEMBL467997 1 -
CHEMBL117166 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL513147 IC50 = 4.9 nM 8.31
CHEMBL467972 IC50 = 5.0 nM 8.30
CHEMBL469053 IC50 = 10.0 nM 8.00
CHEMBL511563 IC50 = 55.0 nM 7.26
CHEMBL469054 IC50 = 90.0 nM 7.05
CHEMBL467560 IC50 = 150.0 nM 6.82
CHEMBL467345 IC50 = 250.0 nM 6.60
CHEMBL468399 IC50 = 350.0 nM 6.46
CHEMBL478629 DORSOMORPHIN IC50 = 430.0 nM 6.37
CHEMBL466765 IC50 = 450.0 nM 6.35
CHEMBL511929 IC50 = 500.0 nM 6.30
CHEMBL511216 IC50 = 500.0 nM 6.30
CHEMBL469055 IC50 = 750.0 nM 6.12
CHEMBL324153 IC50 = 2000.0 nM 5.70
CHEMBL467544 IC50 = 2600.0 nM 5.58
CHEMBL502351 IC50 = 3000.0 nM 5.52
CHEMBL468003 IC50 = 3300.0 nM 5.48
CHEMBL469019 IC50 = 4500.0 nM 5.35
CHEMBL512294 IC50 = 5000.0 nM 5.30
CHEMBL329350 IC50 = 6500.0 nM 5.19
CHEMBL468216 IC50 = 20000.0 nM 4.70
CHEMBL468853 IC50 > 20000.0 nM -
CHEMBL466953 IC50 > 20000.0 nM -
CHEMBL467543 IC50 > 20000.0 nM -
CHEMBL469259 IC50 > 20000.0 nM -
CHEMBL454786 IC50 > 20000.0 nM -
CHEMBL467142 IC50 > 20000.0 nM -
CHEMBL513333 IC50 > 20000.0 nM -
CHEMBL467997 IC50 > 20000.0 nM -
CHEMBL117166 IC50 > 20000.0 nM -