Compound Detail
CHEMBL469565
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Basic Information
| ChEMBL ID | CHEMBL469565 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VQBFRRZTUCYEPI-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
346.4
MW (Da)
2.64
ALogP
5
HBA
1
HBD
71.9
PSA (Ų)
0.90
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 5.16
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform CHEMBL4005 | IC50 | 5.16 | 5.16 | 7000.0 | 1 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform CHEMBL3267 | IC50 | 4.64 | 4.64 | 23000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | IC50 | = | 7000.0 | nM | 5.16 | Inhibition of PI3Kalpha by luminescent kinase glo assay | 19297156 |
| Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | IC50 | = | 23000.0 | nM | 4.64 | Inhibition of PI3Kgamma by luminescent kinase glo assay | 19297156 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19297156 | 10.1016/j.bmcl.2009.02.115 | Unchecked | 1 |
| 19297156 | 10.1016/j.bmcl.2009.02.115 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | 1 |
| 19297156 | 10.1016/j.bmcl.2009.02.115 | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 1 |
Data from ChEMBL 36 via Core Engine