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Compound Detail

CHEMBL470091

PESTALACHLORIDE A
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COc1c(Cl)c(C)c(Cl)c(O)c1C1NC(=O)c2c(O)cc(O)c(CC=C(C)C)c21

Basic Information

ChEMBL ID CHEMBL470091
Name PESTALACHLORIDE A
Phase Preclinical
Structure Type MOL
InChI Key IFONQCDBHMGEFN-UHFFFAOYSA-N
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
15
Publications
0
Known Names

Molecular Properties

438.3
MW (Da)
4.77
ALogP
5
HBA
4
HBD
99.0
PSA (Ų)
0.52
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Small molecule
Availability Unknown
Chirality Unknown

Flags

Natural Product First in Class Prodrug

Extended Properties

Molecular Formula C21H21Cl2NO5
MW 438.31
Aromatic Rings 2
Heavy Atoms 29
NP-Likeness 1.66

Activity Summary

IC50 3 meas. best 6.05

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Fusarium culmorum
CHEMBL612752
IC50 6.05 6.05 890.0 1
Fusarium graminearum
CHEMBL2366834
IC50 4.26 4.26 54400.0 1
Verticillium albo-atrum
CHEMBL613171
IC50 4.23 4.23 58300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
23905700 10.1021/np400301d Molecular identity unknown 5
18694644 10.1016/j.bmc.2008.07.075 Fusarium culmorum 2
18694644 10.1016/j.bmc.2008.07.075 Fusarium graminearum 2
18694644 10.1016/j.bmc.2008.07.075 Verticillium albo-atrum 2
23905700 10.1021/np400301d Staphylococcus aureus 2
23905700 10.1021/np400301d Pseudomonas fluorescens 1
23905700 10.1021/np400301d Aspergillus niger 1
23905700 10.1021/np400301d Pyricularia oryzae 1
23905700 10.1021/np400301d Fusarium graminearum 1
23905700 10.1021/np400301d Fusarium culmorum 1
23905700 10.1021/np400301d Zymoseptoria tritici 1
23905700 10.1021/np400301d Botrytis cinerea 1
23905700 10.1021/np400301d Alternaria mali 1
23905700 10.1021/np400301d Pythium aphanidermatum 1
23905700 10.1021/np400301d Phytophthora infestans 1

Data from ChEMBL 36 via Core Engine