Compound Detail
CHEMBL470610
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Basic Information
| ChEMBL ID | CHEMBL470610 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AWJRAHLZDXQGMM-UHFFFAOYSA-N |
1
Targets
3
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
410.6
MW (Da)
2.88
ALogP
6
HBA
0
HBD
59.1
PSA (Ų)
0.46
QED
0
Ro5 Violations
9
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 3 meas. best 9.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL264 | Ki | 9.08 | 9.08 | 0.8 | 3 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | Ki | = | 0.84 | nM | 9.08 | Displacement of [125I]iodoproxyfan from human histamine H3 receptor expressed in... | 19286376 |
| Histamine H3 receptor | Ki | = | 0.8318 | nM | 9.08 | Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 ... | 24745967 |
| Histamine H3 receptor | Ki | = | 0.84 | nM | 9.08 | Displacement of [3H]N-alpha-methylhistamine from recombinant human histamine H3 ... | 24745967 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 24745967 | 10.1016/j.bmcl.2014.03.098 | Histamine H3 receptor | 2 |
| 19286376 | 10.1016/j.bmcl.2009.02.110 | Histamine H3 receptor | 1 |
Data from ChEMBL 36 via Core Engine