Compound Detail
CHEMBL470620
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Basic Information
| ChEMBL ID | CHEMBL470620 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ORXJSAVDNFYTHE-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
469.4
MW (Da)
5.09
ALogP
4
HBA
2
HBD
61.0
PSA (Ų)
0.41
QED
1
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.7
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase CHEMBL4282 | IC50 | 7.7 | 7.7 | 20.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAC-alpha serine/threonine-protein kinase | IC50 | = | 20.0 | nM | 7.7 | Inhibition of AKT1 | 19285393 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19285393 | 10.1016/j.bmcl.2009.02.094 | RAC-alpha serine/threonine-protein kinase | 1 |
| 19285393 | 10.1016/j.bmcl.2009.02.094 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine