Compound Detail
CHEMBL471524
FORMYCIN Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL471524 |
| Name | FORMYCIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KBHMEHLJSZMEMI-KSYZLYKTSA-N |
3
Targets
4
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
267.2
MW (Da)
-1.91
ALogP
8
HBA
5
HBD
150.4
PSA (Ų)
0.42
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 7.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Influenza A virus CHEMBL613740 | IC50 | 7.54 | 7.54 | 29.0 | 1 |
| L1210 CHEMBL386 | IC50 | 6.0 | 6.0 | 1000.0 | 1 |
| Unchecked CHEMBL612545 | IC50 | 5.64 | 5.335 | 2300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Influenza A virus | IC50 | = | 29.0 | nM | 7.54 | Antiviral activity against Influenza A virus A/WSN/33(H1N1) infected in dog MDCK... | 35092894 |
| L1210 | IC50 | = | 1000.0 | nM | 6.0 | Cytotoxic concentration required to reduce rate of L1210 cell proliferation afte... | 4068000 |
| Unchecked | IC50 | = | 2300.0 | nM | 5.64 | Compound along with 10 uM of erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) was tes... | 3874961 |
| Unchecked | IC50 | = | 9300.0 | nM | 5.03 | Compound evaluated for the inhibitory concentration of S49 Mouse Lymphoma T-cell... | 3874961 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 3820218 | 10.1021/jm00386a007 | L1210 | 4 |
| 3820218 | 10.1021/jm00386a007 | Coxsackievirus B4 | 2 |
| 6737436 | 10.1021/jm00373a020 | Vesicular stomatitis virus | 2 |
| 4068000 | 10.1021/jm00149a033 | Adenosine deaminase | 2 |
| 6737436 | 10.1021/jm00373a020 | Coxsackievirus B4 | 2 |
| 3820218 | 10.1021/jm00386a007 | Vesicular stomatitis virus | 2 |
| 3874961 | 10.1021/jm00146a020 | Unchecked | 2 |
| 3820218 | 10.1021/jm00386a007 | Human alphaherpesvirus 2 | 1 |
| 3820218 | 10.1021/jm00386a007 | Vaccinia virus | 1 |
| 3820218 | 10.1021/jm00386a007 | Human alphaherpesvirus 1 | 1 |
| 3820218 | 10.1021/jm00386a007 | HeLa | 1 |
| 3783585 | 10.1021/jm00161a017 | L1210 | 1 |
| 3820218 | 10.1021/jm00386a007 | Poliovirus 1 | 1 |
| 3820218 | 10.1021/jm00386a007 | Vero | 1 |
| 3820218 | 10.1021/jm00386a007 | Mammalian orthoreovirus 1 | 1 |
| 3820218 | 10.1021/jm00386a007 | Human respirovirus 3 | 1 |
| 35092894 | 10.1016/j.bmc.2022.116613 | MDCK | 1 |
| 3820218 | 10.1021/jm00386a007 | Measles morbillivirus | 1 |
| 3820218 | 10.1021/jm00386a007 | Oryctolagus cuniculus | 1 |
| 3783585 | 10.1021/jm00161a017 | CCRF-CEM | 1 |
Data from ChEMBL 36 via Core Engine