Compound Detail
CHEMBL472039
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL472039 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VNRCMCFRWRKGPN-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
320.4
MW (Da)
1.63
ALogP
5
HBA
4
HBD
106.5
PSA (Ų)
0.35
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.41
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H2 receptor CHEMBL2882 | EC50 | 7.41 | 7.41 | 38.9 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H2 receptor | EC50 | = | 38.9 | nM | 7.41 | Agonist activity at histamine H2 receptor in guinea pig spontaneously beating ri... | 18950149 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18950149 | 10.1021/jm800841w | Histamine H2 receptor | 3 |
| 18950149 | 10.1021/jm800841w | Histamine H1 receptor | 1 |
Data from ChEMBL 36 via Core Engine