Compound Detail
CHEMBL4741011
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Basic Information
| ChEMBL ID | CHEMBL4741011 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | AADFAKZRNCLPGT-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
466.3
MW (Da)
4.01
ALogP
7
HBA
3
HBD
98.2
PSA (Ų)
0.48
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.68
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 3 CHEMBL5432 | IC50 | 5.68 | 5.68 | 2100.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mitogen-activated protein kinase kinase kinase kinase 3 | IC50 | = | 2100.0 | nM | 5.68 | Inhibition of GLK (unknown origin) by alphascreen assay | 29636220 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 29636220 | 10.1016/j.bmcl.2018.03.032 | Mitogen-activated protein kinase kinase kinase kinase 3 | 2 |
Data from ChEMBL 36 via Core Engine