Compound Detail
CHEMBL4748767
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Basic Information
| ChEMBL ID | CHEMBL4748767 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | NYIVQYRLZKFCMF-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
238.2
MW (Da)
2.93
ALogP
2
HBA
2
HBD
66.0
PSA (Ų)
0.72
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.72
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase 4 CHEMBL2897 | IC50 | 6.72 | 6.72 | 190.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Dual specificity mitogen-activated protein kinase kinase 4 | IC50 | = | 190.0 | nM | 6.72 | Inhibition of MEK4 (unknown origin) | 32389527 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32389527 | 10.1016/j.bmcl.2020.127203 | Dual specificity mitogen-activated protein kinase kinase 4 | 2 |
Data from ChEMBL 36 via Core Engine