Compound Detail
CHEMBL4749355
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Basic Information
| ChEMBL ID | CHEMBL4749355 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ALIDHAHGIJCPSV-PSASIEDQSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
244.1
MW (Da)
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.52
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Arginase-1 CHEMBL1075097 | IC50 | 8.52 | 7.23 | 3.0 | 2 |
| Arginase-2, mitochondrial CHEMBL1795148 | IC50 | 8.0 | 6.835 | 10.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Arginase-1 | IC50 | = | 3.0 | nM | 8.52 | Inhibition of human Arg1 by TOGA assay | 32828425 |
| Arginase-2, mitochondrial | IC50 | = | 10.0 | nM | 8.0 | Inhibition of human Arg2 by TOGA assay | 32828425 |
| Arginase-1 | IC50 | = | 1140.0 | nM | 5.94 | Biological Activity of Examples 1 to 30: The inhibitory effects of Examples 1 to... | - |
| Arginase-2, mitochondrial | IC50 | = | 2120.0 | nM | 5.67 | Biological Activity of Examples 1 to 30: The inhibitory effects of Examples 1 to... | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32828425 | 10.1016/j.bmc.2020.115658 | Arginase-1 | 1 |
| 32828425 | 10.1016/j.bmc.2020.115658 | Arginase-2, mitochondrial | 1 |
Data from ChEMBL 36 via Core Engine