Compound Detail
CHEMBL475159
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL475159 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QYEYUIJWYCBKBG-UHFFFAOYSA-N |
1
Targets
3
Activities
2
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
346.5
MW (Da)
4.77
ALogP
3
HBA
1
HBD
42.0
PSA (Ų)
0.73
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 2 meas. best 7.51
Ki 1 meas. best 8.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | Ki | 8.54 | 8.54 | 2.9 | 1 |
| Glucocorticoid receptor CHEMBL2034 | EC50 | 7.51 | 7.04 | 30.7 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | Ki | = | 2.9 | nM | 8.54 | Displacement of FITC-dexamethasone from human recombinant glucocorticoid recepto... | 19321341 |
| Glucocorticoid receptor | EC50 | = | 30.7 | nM | 7.51 | Transrepression activity at GR in IL-1-beta-stimulated human A549 cells assessed... | 19321341 |
| Glucocorticoid receptor | EC50 | = | 268.0 | nM | 6.57 | Transrepression activity at GR in PMA-stimulated human A549 cells assessed as in... | 19321341 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19321341 | 10.1016/j.bmcl.2009.03.006 | Glucocorticoid receptor | 6 |
| 19321341 | 10.1016/j.bmcl.2009.03.006 | Unchecked | 2 |
Data from ChEMBL 36 via Core Engine