Compound Detail
CHEMBL4752870
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Basic Information
| ChEMBL ID | CHEMBL4752870 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | IQFZADSTVFSHDX-UHFFFAOYSA-N |
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
441.8
MW (Da)
3.73
ALogP
6
HBA
1
HBD
84.0
PSA (Ų)
0.62
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.1
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Short transient receptor potential channel 5 CHEMBL1250411 | IC50 | 8.1 | 8.1 | 8.0 | 1 |
| Short transient receptor potential channel 4 CHEMBL4295971 | IC50 | 7.75 | 7.75 | 18.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Short transient receptor potential channel 5 | IC50 | = | 8.0 | nM | 8.1 | Inhibition of TRPC5 (unknown origin) expressed in HEK293 cells assessed as reduc... | 38878518 |
| Short transient receptor potential channel 4 | IC50 | = | 18.0 | nM | 7.75 | Inhibition of TRPC4 (unknown origin) expressed in HEK293 cells assessed as reduc... | 38878518 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33859787 | 10.1021/acsmedchemlett.1c00123 | Short transient receptor potential channel 5 | 1 |
| 38878518 | 10.1016/j.ejmech.2024.116565 | Short transient receptor potential channel 5 | 1 |
| 38878518 | 10.1016/j.ejmech.2024.116565 | Short transient receptor potential channel 3 | 1 |
| 38878518 | 10.1016/j.ejmech.2024.116565 | Short transient receptor potential channel 4 | 1 |
| 38878518 | 10.1016/j.ejmech.2024.116565 | Short transient receptor potential channel 6 | 1 |
| 38878518 | 10.1016/j.ejmech.2024.116565 | Short transient receptor potential channel 7 | 1 |
Data from ChEMBL 36 via Core Engine