Compound Detail
CHEMBL475504
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Basic Information
| ChEMBL ID | CHEMBL475504 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MHLSWVMYXGXNGJ-NHULRPGXSA-N |
2
Targets
2
Activities
2
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
294.3
MW (Da)
-0.68
ALogP
8
HBA
4
HBD
126.7
PSA (Ų)
0.58
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.47
IC50 1 meas. best 4.47
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Nucleic Acid CHEMBL345 | EC50 | 4.47 | 4.47 | 34000.0 | 1 |
| Hepatitis C virus CHEMBL379 | IC50 | 4.47 | 4.47 | 34000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Nucleic Acid | EC50 | = | 34000.0 | nM | 4.47 | Inhibition of HCV RNA replication in a subgenomic bicistronic replicon assay in ... | 15456273 |
| Hepatitis C virus | IC50 | = | 34000.0 | nM | 4.47 | Antiviral activity against Hepatitis C virus | 19112024 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15456273 | 10.1021/jm040068f | Nucleic Acid | 1 |
| 15456273 | 10.1021/jm040068f | NON-PROTEIN TARGET | 1 |
| 19112024 | 10.1016/j.bmc.2008.11.075 | Hepatitis C virus | 1 |
Data from ChEMBL 36 via Core Engine