Assay Detail
Functional
CHEMBL833099
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Inhibition of HCV RNA replication in a subgenomic bicistronic replicon assay in HB-1 cells
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Hepacivirus hominis |
| Cell Type | HB-1 |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Intermediate |
Publication
Structure-activity relationship of heterobase-modified 2'-C-methyl ribonucleosides as inhibitors of hepatitis C virus RNA replication.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 16 | 5.71 | 7.16 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2023964 | — | — | 1 | 7.16 |
| CHEMBL364578 | — | — | 1 | 7.10 |
| CHEMBL2374433 | — | — | 1 | 6.89 |
| CHEMBL2374434 | — | — | 1 | 6.62 |
| CHEMBL236207 | BETA-2'-C-METHYL-7-DEAZA-ADENOSINE | — | 1 | 6.60 |
| CHEMBL73809 | — | — | 1 | 6.58 |
| CHEMBL362765 | — | — | 1 | 5.51 |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | — | 1 | 5.46 |
| CHEMBL475504 | — | — | 1 | 4.47 |
| CHEMBL2374436 | — | — | 1 | 4.16 |
| CHEMBL2374432 | — | — | 1 | 4.00 |
| CHEMBL475702 | — | — | 1 | 4.00 |
| CHEMBL373117 | — | — | 1 | - |
| CHEMBL2374431 | — | — | 1 | - |
| CHEMBL2374435 | — | — | 1 | - |
| CHEMBL2374430 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2023964 | — | EC50 | = | 70.0 | nM | 7.16 |
| CHEMBL364578 | — | EC50 | = | 80.0 | nM | 7.10 |
| CHEMBL2374433 | — | EC50 | = | 130.0 | nM | 6.89 |
| CHEMBL2374434 | — | EC50 | = | 240.0 | nM | 6.62 |
| CHEMBL236207 | BETA-2'-C-METHYL-7-DEAZA-ADENOSINE | EC50 | = | 250.0 | nM | 6.60 |
| CHEMBL73809 | — | EC50 | = | 260.0 | nM | 6.58 |
| CHEMBL362765 | — | EC50 | = | 3100.0 | nM | 5.51 |
| CHEMBL418899 | 2'-B-METHYL-GUANOSINE | EC50 | = | 3500.0 | nM | 5.46 |
| CHEMBL475504 | — | EC50 | = | 34000.0 | nM | 4.47 |
| CHEMBL2374436 | — | EC50 | = | 70000.0 | nM | 4.16 |
| CHEMBL2374432 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL475702 | — | EC50 | = | 100000.0 | nM | 4.00 |
| CHEMBL373117 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2374431 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2374435 | — | EC50 | > | 100000.0 | nM | - |
| CHEMBL2374430 | — | EC50 | > | 100000.0 | nM | - |