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Compound Detail

CHEMBL4759413

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C[C@H](Sc1nc(-c2ccco2)nc2ccccc12)C(=O)N1CCc2ccccc2C1

Basic Information

ChEMBL ID CHEMBL4759413
Phase Preclinical
Structure Type MOL
InChI Key DWWHXUHKCLEEMX-INIZCTEOSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

415.5
MW (Da)
4.96
ALogP
5
HBA
0
HBD
59.2
PSA (Ų)
0.35
QED
0
Ro5 Violations
4
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C24H21N3O2S
MW 415.52
Aromatic Rings 4
Heavy Atoms 30
NP-Likeness -1.72

Activity Summary

Ki 2 meas. best 5.5

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.5 5.5 3162.3 1
Orexin/Hypocretin receptor type 1
CHEMBL5113
Ki 5.05 5.05 8912.5 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32977721 10.1021/acs.jmedchem.0c00964 Orexin/Hypocretin receptor type 1 2
32977721 10.1021/acs.jmedchem.0c00964 Unchecked 1
32977721 10.1021/acs.jmedchem.0c00964 Orexin receptor type 2 1

Data from ChEMBL 36 via Core Engine