Assay Detail
Binding
CHEMBL4730499
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Displacement of [3H]-SB67404 from human orexin 1 receptor expressed in CHO cells incubated for 2 hrs by whole cell radioligand binding assay
124
Total Activities
124
Compounds Tested
3
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | CHO |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Structure-Based Discovery of Novel Ligands for the Orexin 2 Receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| pKi | 60 | - | - |
| IC50 | 34 | - | - |
| Ki | 30 | 5.28 | 8.51 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1083659 | SUVOREXANT | 4.0 | 1 | 8.51 |
| CHEMBL2110363 | — | — | 1 | 8.41 |
| CHEMBL4776564 | — | — | 1 | 7.38 |
| CHEMBL4759509 | — | — | 1 | 5.90 |
| CHEMBL359632 | — | — | 1 | 5.87 |
| CHEMBL4795679 | — | — | 1 | 5.49 |
| CHEMBL4756004 | — | — | 1 | 5.45 |
| CHEMBL2385132 | — | — | 1 | 5.35 |
| CHEMBL4076997 | — | — | 1 | 5.29 |
| CHEMBL4788760 | — | — | 1 | 5.27 |
| CHEMBL4763441 | — | — | 1 | 5.11 |
| CHEMBL4799630 | — | — | 1 | 5.10 |
| CHEMBL4759413 | — | — | 1 | 5.05 |
| CHEMBL4752300 | — | — | 1 | 4.93 |
| CHEMBL4787509 | — | — | 1 | 4.83 |
| CHEMBL4756045 | — | — | 1 | 4.83 |
| CHEMBL4761896 | — | — | 1 | 4.83 |
| CHEMBL4790273 | — | — | 1 | 4.82 |
| CHEMBL4799045 | — | — | 1 | 4.81 |
| CHEMBL4758573 | — | — | 1 | 4.77 |
| CHEMBL4761684 | — | — | 1 | 4.75 |
| CHEMBL4741048 | — | — | 1 | 4.68 |
| CHEMBL4753295 | — | — | 1 | 4.67 |
| CHEMBL4793440 | — | — | 1 | 4.61 |
| CHEMBL4756829 | — | — | 1 | 4.61 |
| CHEMBL4747508 | — | — | 1 | 4.49 |
| CHEMBL4753288 | — | — | 1 | 4.48 |
| CHEMBL4745747 | — | — | 1 | 4.47 |
| CHEMBL4750883 | — | — | 1 | 4.36 |
| CHEMBL4780476 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1083659 | SUVOREXANT | Ki | = | 3.09 | nM | 8.51 |
| CHEMBL2110363 | — | Ki | = | 3.89 | nM | 8.41 |
| CHEMBL4776564 | — | Ki | = | 41.69 | nM | 7.38 |
| CHEMBL4759509 | — | Ki | = | 1258.93 | nM | 5.90 |
| CHEMBL359632 | — | Ki | = | 1348.96 | nM | 5.87 |
| CHEMBL4795679 | — | Ki | = | 3235.94 | nM | 5.49 |
| CHEMBL4756004 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL2385132 | — | Ki | = | 4466.84 | nM | 5.35 |
| CHEMBL4076997 | — | Ki | = | 5128.61 | nM | 5.29 |
| CHEMBL4788760 | — | Ki | = | 5370.32 | nM | 5.27 |
| CHEMBL4763441 | — | Ki | = | 7762.47 | nM | 5.11 |
| CHEMBL4799630 | — | Ki | = | 7943.28 | nM | 5.10 |
| CHEMBL4759413 | — | Ki | = | 8912.51 | nM | 5.05 |
| CHEMBL4752300 | — | Ki | = | 11748.98 | nM | 4.93 |
| CHEMBL4787509 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL4761896 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL4756045 | — | Ki | = | 14791.08 | nM | 4.83 |
| CHEMBL4790273 | — | Ki | = | 15135.61 | nM | 4.82 |
| CHEMBL4799045 | — | Ki | = | 15488.17 | nM | 4.81 |
| CHEMBL4758573 | — | Ki | = | 16982.44 | nM | 4.77 |
| CHEMBL4761684 | — | Ki | = | 17782.79 | nM | 4.75 |
| CHEMBL4741048 | — | Ki | = | 20892.96 | nM | 4.68 |
| CHEMBL4753295 | — | Ki | = | 21379.62 | nM | 4.67 |
| CHEMBL4756829 | — | Ki | = | 24547.09 | nM | 4.61 |
| CHEMBL4793440 | — | Ki | = | 24547.09 | nM | 4.61 |
| CHEMBL4747508 | — | Ki | = | 32359.37 | nM | 4.49 |
| CHEMBL4753288 | — | Ki | = | 33113.11 | nM | 4.48 |
| CHEMBL4745747 | — | Ki | = | 33884.42 | nM | 4.47 |
| CHEMBL4750883 | — | Ki | = | 43651.58 | nM | 4.36 |
| CHEMBL4741042 | — | pKi | - | — | - | |
| CHEMBL4788750 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4778501 | — | Ki | = | 1000000000.0 | nM | - |
| CHEMBL4749594 | — | pKi | - | — | - | |
| CHEMBL4799524 | — | pKi | - | — | - | |
| CHEMBL4756190 | — | pKi | - | — | - | |
| CHEMBL4748304 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4760031 | — | pKi | - | — | - | |
| CHEMBL4755753 | — | pKi | - | — | - | |
| CHEMBL4753145 | — | pKi | - | — | - | |
| CHEMBL4754646 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4780171 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4749246 | — | pKi | - | — | - | |
| CHEMBL4778037 | — | pKi | - | — | - | |
| CHEMBL4790207 | — | pKi | - | — | - | |
| CHEMBL4750232 | — | pKi | - | — | - | |
| CHEMBL4749292 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL4798150 | — | pKi | - | — | - | |
| CHEMBL4745417 | — | pKi | - | — | - | |
| CHEMBL4788931 | — | pKi | - | — | - | |
| CHEMBL4755236 | — | IC50 | > | 100000.0 | nM | - |