Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4799045

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
Cc1ccc(CSCc2ccc(-c3nc(-c4ccccn4)no3)o2)cc1

Basic Information

ChEMBL ID CHEMBL4799045
Phase Preclinical
Structure Type MOL
InChI Key CFNJKHLTWHEJMG-UHFFFAOYSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

363.4
MW (Da)
5.13
ALogP
6
HBA
0
HBD
65.0
PSA (Ų)
0.47
QED
1
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C20H17N3O2S
MW 363.44
Aromatic Rings 4
Heavy Atoms 26
NP-Likeness -1.88

Activity Summary

Ki 2 meas. best 5.07

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Unchecked
CHEMBL612545
Ki 5.07 5.07 8511.4 1
Orexin/Hypocretin receptor type 1
CHEMBL5113
Ki 4.81 4.81 15488.2 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

PubMed DOI Target Context # Activities
32977721 10.1021/acs.jmedchem.0c00964 Unchecked 2
32977721 10.1021/acs.jmedchem.0c00964 Orexin/Hypocretin receptor type 1 1
32977721 10.1021/acs.jmedchem.0c00964 Orexin receptor type 2 1

Data from ChEMBL 36 via Core Engine