Compound Detail
CHEMBL476025
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Basic Information
| ChEMBL ID | CHEMBL476025 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | KMXOCHBBGUIBEI-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
1
Known Names
Molecular Properties
406.4
MW (Da)
3.41
ALogP
5
HBA
3
HBD
102.9
PSA (Ų)
0.58
QED
0
Ro5 Violations
6
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 1 meas. best 5.35
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 CHEMBL2147 | Ki | 5.35 | 5.35 | 4500.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase pim-1 | Ki | = | 4500.0 | nM | 5.35 | Inhibition of human recombinant Pim1 expressed in insect cells by HTRF | 19179076 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19179076 | 10.1016/j.bmcl.2009.01.005 | Serine/threonine-protein kinase pim-1 | 4 |
Data from ChEMBL 36 via Core Engine