Compound Detail
CHEMBL4762145
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COC[C@H](NC(=O)CCc1ccccc1)C(=O)N[C@@H](C)C(=O)NCc1cccc2ccccc12
Basic Information
| ChEMBL ID | CHEMBL4762145 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VCQUUXMHTLIPBD-CYFREDJKSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
461.6
MW (Da)
2.72
ALogP
4
HBA
3
HBD
96.5
PSA (Ų)
0.41
QED
0
Ro5 Violations
11
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 4.67
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Proteasome subunit beta type-8 CHEMBL5620 | IC50 | 4.67 | 4.67 | 21650.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Proteasome subunit beta type-8 | IC50 | = | 21650.0 | nM | 4.67 | Inhibition of human 20S immunoproteasome beta 5 chymotrypsin-like activity | 33095579 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33095579 | 10.1021/acs.jmedchem.0c01520 | Proteasome subunit beta type-8 | 1 |
| 33095579 | 10.1021/acs.jmedchem.0c01520 | Proteasome Macropain subunit MB1 | 1 |
| 33095579 | 10.1021/acs.jmedchem.0c01520 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine