Skip to main content
Free research Free research Free compound review with research home and workspace preview
Quick search ChEMBL 36
Compound Detail

CHEMBL4764455

Enter ChEMBL ID:
Free Research Context This compound will appear in recent viewed items on the research home for this browser.
Research home View demo workspace
NCCNS(=O)(=O)N1C[C@H](CCCB(O)O)[C@](N)(C(=O)O)C1
ChEMBL ↗ Properties Compare Identifier

Basic Information

ChEMBL ID CHEMBL4764455
Phase Preclinical
Structure Type MOL
InChI Key UPENKSHEALUCNG-WPRPVWTQSA-N
2
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names

Molecular Properties

338.2
MW (Da)

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C10H23BN4O6S
MW 338.20

Activity Summary

IC50 2 meas. best 10.0

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Arginase-1
CHEMBL1075097
 IC50 10.0 10.0 0.1 1
Arginase-2, mitochondrial
CHEMBL1795148
 IC50 10.0 10.0 0.1 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Arginase-1 IC50 = 0.1 nM 10.0 Inhibition of human Arg1 32828425
Arginase-2, mitochondrial IC50 = 0.1 nM 10.0 Inhibition of human Arg2 32828425

Literature References

PubMed DOI Target Context # Activities
32828425 10.1016/j.bmc.2020.115658 Arginase-1 1
32828425 10.1016/j.bmc.2020.115658 Arginase-2, mitochondrial 1

Data from ChEMBL 36 via Core Engine