Compound Detail
CHEMBL477175
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Basic Information
| ChEMBL ID | CHEMBL477175 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | BIVCSCVSPSZJON-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
3
PK Parameters
2
Publications
0
Known Names
Molecular Properties
383.4
MW (Da)
5.62
ALogP
2
HBA
3
HBD
73.3
PSA (Ų)
0.42
QED
1
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 7.17
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Thrombopoietin receptor CHEMBL1864 | EC50 | 7.17 | 7.17 | 67.0 | 1 |
Pharmacokinetic Data
| Parameter | Value | Units | Species |
|---|---|---|---|
| Cmax | 2000.0 | nM | Mus musculus |
| F | 10.0 | % | Mus musculus |
| T1/2 | 4.1 | hr | Mus musculus |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Thrombopoietin receptor | EC50 | = | 67.0 | nM | 7.17 | Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as act... | 18778936 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 18778936 | 10.1016/j.bmcl.2008.08.068 | Mus musculus | 3 |
| 18778936 | 10.1016/j.bmcl.2008.08.068 | Thrombopoietin receptor | 2 |
Data from ChEMBL 36 via Core Engine