Assay Detail
Functional
CHEMBL987061
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at human thrombopoietin receptor in Ba/F3 cells assessed as activation of Stat5 response element-driven reporter gene expression
37
Total Activities
37
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | BaF3 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and biological evaluation of benzo[a]carbazole-based small molecule agonists of the thrombopoietin (Tpo) receptor.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 37 | 6.60 | 7.58 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL479081 | — | — | 1 | 7.58 |
| CHEMBL477381 | — | — | 1 | 7.46 |
| CHEMBL461101 | ELTROMBOPAG | 4.0 | 1 | 7.42 |
| CHEMBL518285 | — | — | 1 | 7.39 |
| CHEMBL479083 | — | — | 1 | 7.37 |
| CHEMBL477400 | — | — | 1 | 7.26 |
| CHEMBL477174 | — | — | 1 | 7.19 |
| CHEMBL477175 | — | — | 1 | 7.17 |
| CHEMBL516272 | — | — | 1 | 7.12 |
| CHEMBL477195 | — | — | 1 | 6.96 |
| CHEMBL489367 | — | — | 1 | 6.96 |
| CHEMBL477401 | — | — | 1 | 6.92 |
| CHEMBL479093 | — | — | 1 | 6.90 |
| CHEMBL491798 | — | — | 1 | 6.84 |
| CHEMBL515795 | — | — | 1 | 6.83 |
| CHEMBL521746 | — | — | 1 | 6.71 |
| CHEMBL492017 | — | — | 1 | 6.63 |
| CHEMBL476556 | — | — | 1 | 6.55 |
| CHEMBL523460 | — | — | 1 | 6.48 |
| CHEMBL489365 | — | — | 1 | 6.43 |
| CHEMBL479082 | — | — | 1 | 6.34 |
| CHEMBL490585 | — | — | 1 | 6.33 |
| CHEMBL521768 | — | — | 1 | 6.25 |
| CHEMBL490586 | — | — | 1 | 6.10 |
| CHEMBL489388 | — | — | 1 | 6.06 |
| CHEMBL490412 | — | — | 1 | 5.89 |
| CHEMBL490409 | — | — | 1 | 5.47 |
| CHEMBL523147 | — | — | 1 | 5.11 |
| CHEMBL448025 | — | — | 1 | 5.11 |
| CHEMBL522978 | — | — | 1 | 5.04 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL479081 | — | EC50 | = | 26.0 | nM | 7.58 |
| CHEMBL477381 | — | EC50 | = | 35.0 | nM | 7.46 |
| CHEMBL461101 | ELTROMBOPAG | EC50 | = | 38.0 | nM | 7.42 |
| CHEMBL518285 | — | EC50 | = | 41.0 | nM | 7.39 |
| CHEMBL479083 | — | EC50 | = | 43.0 | nM | 7.37 |
| CHEMBL477400 | — | EC50 | = | 55.0 | nM | 7.26 |
| CHEMBL477174 | — | EC50 | = | 65.0 | nM | 7.19 |
| CHEMBL477175 | — | EC50 | = | 67.0 | nM | 7.17 |
| CHEMBL516272 | — | EC50 | = | 76.0 | nM | 7.12 |
| CHEMBL489367 | — | EC50 | = | 109.0 | nM | 6.96 |
| CHEMBL477195 | — | EC50 | = | 111.0 | nM | 6.96 |
| CHEMBL477401 | — | EC50 | = | 119.0 | nM | 6.92 |
| CHEMBL479093 | — | EC50 | = | 127.0 | nM | 6.90 |
| CHEMBL491798 | — | EC50 | = | 143.0 | nM | 6.84 |
| CHEMBL515795 | — | EC50 | = | 148.0 | nM | 6.83 |
| CHEMBL521746 | — | EC50 | = | 194.0 | nM | 6.71 |
| CHEMBL492017 | — | EC50 | = | 232.0 | nM | 6.63 |
| CHEMBL476556 | — | EC50 | = | 284.0 | nM | 6.55 |
| CHEMBL523460 | — | EC50 | = | 333.0 | nM | 6.48 |
| CHEMBL489365 | — | EC50 | = | 373.0 | nM | 6.43 |
| CHEMBL479082 | — | EC50 | = | 452.0 | nM | 6.34 |
| CHEMBL490585 | — | EC50 | = | 473.0 | nM | 6.33 |
| CHEMBL521768 | — | EC50 | = | 569.0 | nM | 6.25 |
| CHEMBL490586 | — | EC50 | = | 799.0 | nM | 6.10 |
| CHEMBL489388 | — | EC50 | = | 870.0 | nM | 6.06 |
| CHEMBL490412 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL490409 | — | EC50 | = | 3400.0 | nM | 5.47 |
| CHEMBL448025 | — | EC50 | = | 7790.0 | nM | 5.11 |
| CHEMBL523147 | — | EC50 | = | 7830.0 | nM | 5.11 |
| CHEMBL522978 | — | EC50 | = | 9200.0 | nM | 5.04 |
| CHEMBL522280 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL514557 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL490410 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL490411 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL521797 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL491804 | — | EC50 | > | 30000.0 | nM | - |
| CHEMBL489366 | — | EC50 | > | 30000.0 | nM | - |