Compound Detail
CHEMBL4783102
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Basic Information
| ChEMBL ID | CHEMBL4783102 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SOWTUSBRJBRQBT-CSKARUKUSA-N |
3
Targets
3
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
344.4
MW (Da)
4.88
ALogP
3
HBA
2
HBD
53.6
PSA (Ų)
0.54
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 3 meas. best 8.06
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| High affinity nerve growth factor receptor CHEMBL2815 | IC50 | 8.06 | 8.06 | 8.8 | 1 |
| BDNF/NT-3 growth factors receptor CHEMBL4898 | IC50 | 7.44 | 7.44 | 36.2 | 1 |
| NT-3 growth factor receptor CHEMBL5608 | IC50 | 7.28 | 7.28 | 52.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| High affinity nerve growth factor receptor | IC50 | = | 8.8 | nM | 8.06 | Inhibition of TrkA (unknown origin) using Tyr1 peptide as substrate in presence ... | 32702585 |
| BDNF/NT-3 growth factors receptor | IC50 | = | 36.2 | nM | 7.44 | Inhibition of TrkB (unknown origin) using Tyr1 peptide as substrate in presence ... | 32702585 |
| NT-3 growth factor receptor | IC50 | = | 52.0 | nM | 7.28 | Inhibition of TrkC (unknown origin) using Tyr1 peptide as substrate in presence ... | 32702585 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 32702585 | 10.1016/j.ejmech.2020.112552 | High affinity nerve growth factor receptor | 1 |
| 32702585 | 10.1016/j.ejmech.2020.112552 | BDNF/NT-3 growth factors receptor | 1 |
| 32702585 | 10.1016/j.ejmech.2020.112552 | NT-3 growth factor receptor | 1 |
Data from ChEMBL 36 via Core Engine