Compound Detail
CHEMBL4785324
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Basic Information
| ChEMBL ID | CHEMBL4785324 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RCSDMZMTLQPVDG-ICSRJNTNSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
417.6
MW (Da)
2.90
ALogP
6
HBA
2
HBD
96.5
PSA (Ų)
0.62
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 6.08
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Signal peptide peptidase-like 2A CHEMBL4105833 | IC50 | 6.08 | 6.08 | 840.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Signal peptide peptidase-like 2A | IC50 | = | 840.0 | nM | 6.08 | Inhibition of human SPPL2a expressed in HEK293 cells cotransfected with Gal4 luc... | 31223443 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 31223443 | 10.1021/acsmedchemlett.9b00044 | Signal peptide peptidase-like 2A | 1 |
| 31223443 | 10.1021/acsmedchemlett.9b00044 | Gamma-secretase | 1 |
Data from ChEMBL 36 via Core Engine