Compound Detail
CHEMBL4786185
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C#CCCNC(=O)c1c(C)[nH]c(/C=C2\C(=O)Nc3ccc(C(=O)N[C@H](C)c4ccccc4)cc32)c1C
Basic Information
| ChEMBL ID | CHEMBL4786185 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SEAKQGYJVIVQFU-MPGAHLTBSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
480.6
MW (Da)
4.37
ALogP
3
HBA
4
HBD
103.1
PSA (Ų)
0.23
QED
0
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.04
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 5 CHEMBL5678 | IC50 | 7.04 | 7.04 | 91.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| G protein-coupled receptor kinase 5 | IC50 | = | 91.0 | nM | 7.04 | Inhibition of human GRK5 using porcine brain tubulin as substrate incubated for ... | 33393767 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33393767 | 10.1021/acs.jmedchem.0c01522 | G protein-coupled receptor kinase 5 | 2 |
| 33393767 | 10.1021/acs.jmedchem.0c01522 | Unchecked | 2 |
| 33393767 | 10.1021/acs.jmedchem.0c01522 | Beta-adrenergic receptor kinase 1 | 1 |
Data from ChEMBL 36 via Core Engine