Compound Detail
CHEMBL4789512
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Basic Information
| ChEMBL ID | CHEMBL4789512 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | JYWKQBXQTCRMGP-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
377.4
MW (Da)
3.42
ALogP
5
HBA
1
HBD
64.7
PSA (Ų)
0.76
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Potassium channel subfamily T member 1 CHEMBL4739688 | IC50 | 5.8 | 5.8 | 1597.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Potassium channel subfamily T member 1 | IC50 | = | 1597.0 | nM | 5.8 | Inhibition of recombinant wild type human KNa1.1 expressed in human HEK-TREX cel... | 33859800 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 33859800 | 10.1021/acsmedchemlett.0c00675 | Potassium channel subfamily T member 1 | 1 |
Data from ChEMBL 36 via Core Engine