Compound Detail
CHEMBL479287
ANGELOYLGOMISIN Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
C/C=C(/C)C(=O)Oc1c(OC)c(OC)cc2c1-c1c(cc(OC)c(OC)c1OC)CC(C)(O)C(C)C2
Basic Information
| ChEMBL ID | CHEMBL479287 |
| Name | ANGELOYLGOMISIN |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ZSAUXCVJDYCLRS-GDNBJRDFSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
500.6
MW (Da)
4.75
ALogP
8
HBA
1
HBD
92.7
PSA (Ų)
0.33
QED
1
Ro5 Violations
7
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 4.34
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| HL-60 CHEMBL383 | IC50 | 4.34 | 4.215 | 45300.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| HL-60 | IC50 | = | 45300.0 | nM | 4.34 | Cytotoxicity against human HL60 cells by XTT assay | 16562834 |
| HL-60 | IC50 | = | 81500.0 | nM | 4.09 | Antioxidant activity in human HL60 cells assessed as inhibition of TPA-stimulate... | 16562834 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 16562834 | 10.1021/np0503707 | HL-60 | 2 |
| 16562834 | 10.1021/np0503707 | Vero | 1 |
| 16562834 | 10.1021/np0503707 | LLC-PK1 | 1 |
| 16562834 | 10.1021/np0503707 | SK-MEL | 1 |
| 16562834 | 10.1021/np0503707 | KB | 1 |
| 16562834 | 10.1021/np0503707 | BT-549 | 1 |
| 16562834 | 10.1021/np0503707 | SK-OV-3 | 1 |
| 16562834 | 10.1021/np0503707 | NON-PROTEIN TARGET | 1 |
| 16562834 | 10.1021/np0503707 | Prostaglandin G/H synthase 2 | 1 |
Data from ChEMBL 36 via Core Engine