Compound Detail
CHEMBL479515
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Basic Information
| ChEMBL ID | CHEMBL479515 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | MDUQIEXQKMPARD-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
476.1
MW (Da)
1.49
ALogP
6
HBA
3
HBD
108.8
PSA (Ų)
0.60
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.05
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Histamine H3 receptor CHEMBL5076 | IC50 | 5.05 | 5.05 | 9000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Histamine H3 receptor | IC50 | = | 9000.0 | nM | 5.05 | Binding affinity to histamine H3 receptor in guinea pig brain membrane | 8158162 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 8158162 | 10.1021/np50103a029 | Histamine H3 receptor | 2 |
Data from ChEMBL 36 via Core Engine