Compound Detail
CHEMBL4802039
JNJ-65355394 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL4802039 |
| Name | JNJ-65355394 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | CYFBRQHYEQKYHH-MRXNPFEDSA-N |
2
Targets
4
Activities
2
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
358.5
MW (Da)
3.57
ALogP
5
HBA
1
HBD
58.1
PSA (Ų)
0.89
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 8.89
Ki 2 meas. best 6.13
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Protein O-GlcNAcase CHEMBL5921 | IC50 | 8.89 | 8.65 | 1.3 | 2 |
| Kappa-type opioid receptor CHEMBL237 | Ki | 6.13 | 6.12 | 741.3 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Protein O-GlcNAcase | IC50 | = | 1.3 | nM | 8.89 | Fluorescence-based enzymatic assay | - |
| Protein O-GlcNAcase | IC50 | = | 3.9 | nM | 8.41 | Cell-based OGA assay | - |
| Kappa-type opioid receptor | Ki | = | 741.31 | nM | 6.13 | GPCRScan assay: inhibition of KOR | - |
| Kappa-type opioid receptor | Ki | = | 773.3 | nM | 6.11 | GPCRScan assay: inhibition of KOR | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4800731 | Unchecked | 10 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.6019/CHEMBL5303304 | U2OS | 6 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 5 |
| - | 10.6019/CHEMBL4800731 | Kappa-type opioid receptor | 4 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 4 |
| - | 10.6019/CHEMBL4800731 | Alpha-2A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4800731 | Protein O-GlcNAcase | 2 |
| - | 10.6019/CHEMBL4800731 | Alpha-1A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4800731 | 5-hydroxytryptamine receptor 1B | 2 |
| - | 10.6019/CHEMBL4800731 | 5-hydroxytryptamine receptor 5A | 2 |
| - | 10.6019/CHEMBL4800731 | 5-hydroxytryptamine receptor 6 | 2 |
| - | 10.6019/CHEMBL4800731 | Delta-type opioid receptor | 2 |
| - | 10.6019/CHEMBL4800731 | 5-hydroxytryptamine receptor 1A | 2 |
| - | 10.6019/CHEMBL4800731 | D(2) dopamine receptor | 2 |
| - | 10.6019/CHEMBL4800731 | 5-hydroxytryptamine receptor 7 | 2 |
| - | 10.6019/CHEMBL4800731 | Muscarinic acetylcholine receptor M3 | 2 |
Data from ChEMBL 36 via Core Engine