Assay Detail
Binding
CHEMBL4888252
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Cell-based OGA assay
2
Total Activities
2
Compounds Tested
1
Activity Types
1
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Data for DCP probe JNJ-65355394
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 8.41 | 8.41 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Additional information | Additional information | - | — | High content screening (Perkin Elmer opera phenix) using a monoclonal antibody detecting all GlcNAcylated protein levels (CTD110.6 Cell signaling 9875) in HEK cells overexpressing P301L mutant human Tau: |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4802039 | JNJ-65355394 | — | 1 | 8.41 |
| CHEMBL4802044 | JNJ-73924149 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4802039 | JNJ-65355394 | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL4802044 | JNJ-73924149 | IC50 | > | 1.0 | nM | - |