Compound Detail
CHEMBL4802044
JNJ-73924149 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL4802044 |
| Name | JNJ-73924149 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VKYYOTCDIVOPRO-MRXNPFEDSA-N |
5
Targets
10
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
358.5
MW (Da)
3.57
ALogP
5
HBA
1
HBD
58.1
PSA (Ų)
0.89
QED
0
Ro5 Violations
5
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
Ki 10 meas. best 7.2
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 CHEMBL287 | Ki | 7.2 | 7.2 | 63.1 | 2 |
| Sigma intracellular receptor 2 CHEMBL4105907 | Ki | 5.87 | 5.86 | 1349.0 | 2 |
| Sodium-dependent serotonin transporter CHEMBL228 | Ki | 5.59 | 5.585 | 2570.4 | 2 |
| Alpha-2B adrenergic receptor CHEMBL1942 | Ki | 5.43 | 5.43 | 3672.8 | 2 |
| Sodium-dependent dopamine transporter CHEMBL238 | Ki | 5.28 | 5.28 | 5248.1 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Ki | = | 63.33 | nM | 7.2 | GPCRScan assay: inhibition of Sigma 1 | - |
| Sigma non-opioid intracellular receptor 1 | Ki | = | 63.1 | nM | 7.2 | GPCRScan assay: inhibition of Sigma 1 | - |
| Sigma intracellular receptor 2 | Ki | = | 1348.96 | nM | 5.87 | GPCRScan assay: inhibition of Sigma 2 | - |
| Sigma intracellular receptor 2 | Ki | = | 1399.16 | nM | 5.85 | GPCRScan assay: inhibition of Sigma 2 | - |
| Sodium-dependent serotonin transporter | Ki | = | 2570.4 | nM | 5.59 | GPCRScan assay: inhibition of SERT | - |
| Sodium-dependent serotonin transporter | Ki | = | 2614.09 | nM | 5.58 | GPCRScan assay: inhibition of SERT | - |
| Alpha-2B adrenergic receptor | Ki | = | 3691.26 | nM | 5.43 | GPCRScan assay: inhibition of Alpha2B | - |
| Alpha-2B adrenergic receptor | Ki | = | 3672.82 | nM | 5.43 | GPCRScan assay: inhibition of Alpha2B | - |
| Sodium-dependent dopamine transporter | Ki | = | 5284.45 | nM | 5.28 | GPCRScan assay: inhibition of DAT | - |
| Sodium-dependent dopamine transporter | Ki | = | 5248.07 | nM | 5.28 | GPCRScan assay: inhibition of DAT | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5303304 | HEK-293T | 7 |
| - | 10.6019/CHEMBL5303304 | Fibroblast | 7 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL4800731 | Alpha-2B adrenergic receptor | 3 |
| - | 10.6019/CHEMBL4800731 | Sigma intracellular receptor 2 | 3 |
| - | 10.6019/CHEMBL4800731 | Sodium-dependent dopamine transporter | 3 |
| - | 10.6019/CHEMBL4800731 | Sodium-dependent serotonin transporter | 3 |
| - | 10.6019/CHEMBL4800731 | Sigma non-opioid intracellular receptor 1 | 3 |
| - | 10.6019/CHEMBL5303304 | U2OS | 3 |
| - | 10.6019/CHEMBL4800731 | GABA-A receptor; anion channel | 2 |
| - | 10.6019/CHEMBL4800731 | Protein O-GlcNAcase | 2 |
| - | 10.6019/CHEMBL4800731 | Alpha-1A adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4800731 | Alpha-1D adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4800731 | Beta-1 adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4800731 | Beta-2 adrenergic receptor | 1 |
| - | 10.6019/CHEMBL4800731 | Muscarinic acetylcholine receptor M2 | 1 |
| - | 10.6019/CHEMBL4800731 | 5-hydroxytryptamine receptor 1D | 1 |
Data from ChEMBL 36 via Core Engine