Assay Detail
Binding
CHEMBL4880053
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GPCRScan assay: inhibition of Alpha2B
221
Total Activities
181
Compounds Tested
2
Activity Types
12
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
SGC PDSP GPCRScan assays
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Inhibition | 181 | - | - |
| Ki | 40 | 5.62 | 6.37 |
Assay Parameters
| Parameter | Type | Value | Units | Text |
|---|---|---|---|---|
| Parental cells | Parental cells | - | — | HEKT |
| PMID | PMID | - | — | 18486470/23069764/6276200 |
| Protein length | Protein length | - | — | full-length |
| Radioligand conc. used [nM] | Radioligand conc. used [nM] | - | — | 1.5 – 2.0 |
| Radioligand Kd | Radioligand Kd | 1.81 | nM | — |
| Radioligand name | Radioligand name | - | — | [3H]-Rauwolscine |
| Radioligand pKd | Radioligand pKd | 8.74 | — | — |
| Radioligand pKd ± SEM | Radioligand pKd ± SEM | 0.13 | — | — |
| Reference ligand | Reference ligand | - | — | Yohimbine |
| Reference ligand Ki | Reference ligand Ki | 5.81 | nM | — |
| Reference ligand pKi | Reference ligand pKi | 8.24 | — | — |
| Reference ligand pKi ± SEM | Reference ligand pKi ± SEM | 0.02 | — | — |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4748908 | TP-040n | — | 3 | 6.37 |
| CHEMBL4520788 | BAY-294 | — | 3 | 6.09 |
| CHEMBL4558518 | GSI-NC | — | 3 | 6.06 |
| CHEMBL4535474 | BAY-293 | — | 3 | 5.91 |
| CHEMBL3582478 | MSD-CYP11B2 | — | 3 | 5.84 |
| CHEMBL4576555 | T3-CLK-N | — | 3 | 5.79 |
| CHEMBL4578164 | MRL-CB1-NC | — | 3 | 5.77 |
| CHEMBL4566600 | PPTN-NC | — | 3 | 5.74 |
| CHEMBL1800685 | PPTN | — | 3 | 5.59 |
| CHEMBL3480577 | UCSF924 | — | 3 | 5.59 |
| CHEMBL4778870 | TP-040 | — | 3 | 5.59 |
| CHEMBL4549667 | TP-030-2 | — | 3 | 5.55 |
| CHEMBL5094181 | — | — | 3 | 5.45 |
| CHEMBL4802044 | JNJ-73924149 | — | 3 | 5.43 |
| CHEMBL4513786 | A-545 | — | 3 | 5.38 |
| CHEMBL4521594 | BAY-1797 | — | 3 | 5.37 |
| CHEMBL4588900 | BI 1230 | — | 3 | 5.35 |
| CHEMBL4802042 | JNJ-54119936 | — | 3 | 5.04 |
| CHEMBL4647642 | BAY-173 | — | 3 | 5.00 |
| CHEMBL3697701 | A-079 | — | 1 | - |
| CHEMBL3701197 | A-226 | — | 1 | - |
| CHEMBL4586794 | ABT-100 | — | 1 | - |
| CHEMBL4526341 | A-108 | — | 1 | - |
| CHEMBL111612 | ABT-546 | — | 1 | - |
| CHEMBL332794 | A-192621 | — | 1 | - |
| CHEMBL4093612 | A-1596586 | — | 1 | - |
| CHEMBL4066040 | A-1596584 | — | 1 | - |
| CHEMBL4593677 | BAY-474 | — | 1 | - |
| CHEMBL4522773 | BAY-827 | — | 1 | - |
| CHEMBL4585243 | BAY-7598 | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4748908 | TP-040n | Ki | = | 426.58 | nM | 6.37 |
| CHEMBL4748908 | TP-040n | Ki | = | 475.35 | nM | 6.32 |
| CHEMBL4520788 | BAY-294 | Ki | = | 812.83 | nM | 6.09 |
| CHEMBL4520788 | BAY-294 | Ki | = | 846.75 | nM | 6.07 |
| CHEMBL4558518 | GSI-NC | Ki | = | 870.96 | nM | 6.06 |
| CHEMBL4558518 | GSI-NC | Ki | = | 879.0 | nM | 6.06 |
| CHEMBL4535474 | BAY-293 | Ki | = | 1226.87 | nM | 5.91 |
| CHEMBL4535474 | BAY-293 | Ki | = | 1230.27 | nM | 5.91 |
| CHEMBL3582478 | MSD-CYP11B2 | Ki | = | 1439.13 | nM | 5.84 |
| CHEMBL3582478 | MSD-CYP11B2 | Ki | = | 1445.44 | nM | 5.84 |
| CHEMBL4576555 | T3-CLK-N | Ki | = | 1621.81 | nM | 5.79 |
| CHEMBL4576555 | T3-CLK-N | Ki | = | 1646.19 | nM | 5.78 |
| CHEMBL4578164 | MRL-CB1-NC | Ki | = | 1694.0 | nM | 5.77 |
| CHEMBL4578164 | MRL-CB1-NC | Ki | = | 1698.24 | nM | 5.77 |
| CHEMBL4566600 | PPTN-NC | Ki | = | 1836.54 | nM | 5.74 |
| CHEMBL4566600 | PPTN-NC | Ki | = | 1819.7 | nM | 5.74 |
| CHEMBL1800685 | PPTN | Ki | = | 2561.53 | nM | 5.59 |
| CHEMBL3480577 | UCSF924 | Ki | = | 2570.4 | nM | 5.59 |
| CHEMBL1800685 | PPTN | Ki | = | 2570.4 | nM | 5.59 |
| CHEMBL4778870 | TP-040 | Ki | = | 2570.64 | nM | 5.59 |
| CHEMBL4778870 | TP-040 | Ki | = | 2570.4 | nM | 5.59 |
| CHEMBL4549667 | TP-030-2 | Ki | = | 2818.38 | nM | 5.55 |
| CHEMBL4549667 | TP-030-2 | Ki | = | 2870.29 | nM | 5.54 |
| CHEMBL3480577 | UCSF924 | Ki | = | 3037.33 | nM | 5.52 |
| CHEMBL5094181 | — | Ki | = | 3579.32 | nM | 5.45 |
| CHEMBL5094181 | — | Ki | = | 3548.13 | nM | 5.45 |
| CHEMBL4802044 | JNJ-73924149 | Ki | = | 3672.82 | nM | 5.43 |
| CHEMBL4802044 | JNJ-73924149 | Ki | = | 3691.26 | nM | 5.43 |
| CHEMBL4513786 | A-545 | Ki | = | 4168.69 | nM | 5.38 |
| CHEMBL4521594 | BAY-1797 | Ki | = | 4285.88 | nM | 5.37 |
| CHEMBL4521594 | BAY-1797 | Ki | = | 4315.19 | nM | 5.37 |
| CHEMBL4588900 | BI 1230 | Ki | = | 4466.84 | nM | 5.35 |
| CHEMBL4588900 | BI 1230 | Ki | = | 4486.58 | nM | 5.35 |
| CHEMBL4513786 | A-545 | Ki | = | 4643.5 | nM | 5.33 |
| CHEMBL4802042 | JNJ-54119936 | Ki | = | 9120.11 | nM | 5.04 |
| CHEMBL4802042 | JNJ-54119936 | Ki | = | 9223.59 | nM | 5.04 |
| CHEMBL4647642 | BAY-173 | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4647642 | BAY-173 | Ki | = | 10000.0 | nM | 5.00 |
| CHEMBL4518706 | PF-00911705 | Inhibition | = | -4.21 | % | - |
| CHEMBL4531775 | SR-321 | Inhibition | = | 1.13 | % | - |
| CHEMBL3137331 | DEFACTINIB | Inhibition | = | 5.76 | % | - |
| CHEMBL4577237 | BI 9446 | Inhibition | = | 14.99 | % | - |
| CHEMBL4530740 | BI 1950 | Inhibition | = | -3.79 | % | - |
| CHEMBL4552554 | PF-04475866 | Inhibition | = | 12.13 | % | - |
| CHEMBL3286797 | PF-04418948 | Inhibition | = | 9.24 | % | - |
| CHEMBL2204283 | MSD-M1PAM-NC | Inhibition | = | -2.99 | % | - |
| CHEMBL1800285 | MSD-M1PAM | Inhibition | = | -6.86 | % | - |
| CHEMBL4638939 | GSK943 | Inhibition | = | 22.8 | % | - |
| CHEMBL4637208 | GSK973 | Inhibition | = | 12.48 | % | - |
| CHEMBL4643852 | BAY-6672 | Inhibition | = | -20.89 | % | - |