Compound Detail
CHEMBL4593677
BAY-474 Enter ChEMBL ID:
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Basic Information
| ChEMBL ID | CHEMBL4593677 |
| Name | BAY-474 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | QKVFMAAIXZONRN-UHFFFAOYSA-N |
2
Targets
4
Activities
1
Assay Types
0
PK Parameters
20
Publications
0
Known Names
Molecular Properties
289.3
MW (Da)
3.15
ALogP
4
HBA
2
HBD
88.3
PSA (Ų)
0.84
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 4 meas. best 8.54
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Hepatocyte growth factor receptor CHEMBL3717 | IC50 | 8.54 | 8.54 | 2.9 | 2 |
| Ribosomal protein S6 kinase alpha-3 CHEMBL2345 | IC50 | 6.05 | 6.05 | 900.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Hepatocyte growth factor receptor | IC50 | = | 2.9 | nM | 8.54 | Cellular mechanistic assay using NKM-45 cells and p-MET | - |
| Hepatocyte growth factor receptor | IC50 | = | 2.9 | nM | 8.54 | Affinity On-target Cellular interaction (Cellular mechanistic assay (phosphoryla... | - |
| Ribosomal protein S6 kinase alpha-3 | IC50 | = | 900.0 | nM | 6.05 | Rsk2 (h) Millipore kinase activity assay | - |
| Ribosomal protein S6 kinase alpha-3 | IC50 | = | 900.0 | nM | 6.05 | Selectivity interaction (Enzyme panel (Millipore)) EUB0000293b RPS6KA3 | - |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| - | 10.6019/CHEMBL4507263 | Unchecked | 18 |
| - | 10.6019/CHEMBL5724558 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL5674860 | Colon cancer organoid | 12 |
| - | 10.6019/CHEMBL4689842 | U2OS | 10 |
| - | 10.6019/CHEMBL4689842 | Fibroblast | 10 |
| - | 10.6019/CHEMBL5724696 | U2OS | 8 |
| - | 10.6019/CHEMBL5608141 | Colon cancer organoid | 6 |
| - | 10.1158/2159-8290.CD-23-0050 | Colon cancer organoid | 5 |
| - | 10.6019/CHEMBL4689842 | HEK-293T | 3 |
| - | 10.6019/CHEMBL4507263 | Sigma non-opioid intracellular receptor 1 | 3 |
| - | 10.6019/CHEMBL4507263 | Hepatocyte growth factor receptor | 3 |
| - | 10.6019/CHEMBL4507263 | D(2) dopamine receptor | 2 |
| - | 10.6019/CHEMBL4507263 | Alpha-1D adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4507263 | Alpha-2A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4507263 | Alpha-1B adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4507263 | Alpha-1A adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4507263 | D(3) dopamine receptor | 2 |
| - | 10.6019/CHEMBL4507263 | Voltage-dependent L-type calcium channel subunit alpha-1C | 2 |
| - | 10.6019/CHEMBL4507263 | Beta-2 adrenergic receptor | 2 |
| - | 10.6019/CHEMBL4507263 | D(1A) dopamine receptor | 2 |
Data from ChEMBL 36 via Core Engine