Compound Detail
CHEMBL480354
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL480354 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | UAUDFVXPXLPWFH-YFHOEESVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
1
Publications
0
Known Names
Molecular Properties
345.4
MW (Da)
0.14
ALogP
6
HBA
5
HBD
118.6
PSA (Ų)
0.50
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.77
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 5.77 | 5.77 | 1700.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 | IC50 | = | 1700.0 | nM | 5.77 | Inhibition of CHK1 | 19111462 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19111462 | 10.1016/j.bmcl.2008.12.001 | Serine/threonine-protein kinase Chk1 | 1 |
Data from ChEMBL 36 via Core Engine