Assay Detail
Binding
CHEMBL990372
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Inhibition of CHK1
23
Total Activities
23
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Intermediate |
Target
Serine/threonine-protein kinase Chk1 (CHEMBL4630) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Synthesis and CHK1 inhibitory potency of Hymenialdisine analogues.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 23 | 6.59 | 7.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL507188 | — | — | 1 | 7.85 |
| CHEMBL480187 | — | — | 1 | 7.54 |
| CHEMBL480350 | — | — | 1 | 7.00 |
| CHEMBL474608 | — | — | 1 | 6.85 |
| CHEMBL519119 | — | — | 1 | 6.82 |
| CHEMBL520929 | — | — | 1 | 6.82 |
| CHEMBL511293 | — | — | 1 | 6.75 |
| CHEMBL470758 | — | — | 1 | 6.72 |
| CHEMBL512336 | — | — | 1 | 6.64 |
| CHEMBL517241 | — | — | 1 | 6.58 |
| CHEMBL470937 | — | — | 1 | 6.55 |
| CHEMBL481495 | — | — | 1 | 6.52 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | — | 1 | 6.48 |
| CHEMBL514818 | — | — | 1 | 6.34 |
| CHEMBL332551 | — | — | 1 | 6.33 |
| CHEMBL475444 | — | — | 1 | 6.05 |
| CHEMBL481332 | — | — | 1 | 5.89 |
| CHEMBL480354 | — | — | 1 | 5.77 |
| CHEMBL361708 | HYMENIALDISINE | — | 1 | 5.72 |
| CHEMBL481494 | — | — | 1 | - |
| CHEMBL519118 | — | — | 1 | - |
| CHEMBL518466 | — | — | 1 | - |
| CHEMBL480189 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL507188 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL480187 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL480350 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL474608 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL519119 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL520929 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL511293 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL470758 | — | IC50 | = | 190.0 | nM | 6.72 |
| CHEMBL512336 | — | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL517241 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL470937 | — | IC50 | = | 280.0 | nM | 6.55 |
| CHEMBL481495 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL255465 | DEBROMOHYMENIALDISINE | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL514818 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL332551 | — | IC50 | = | 470.0 | nM | 6.33 |
| CHEMBL475444 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL481332 | — | IC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL480354 | — | IC50 | = | 1700.0 | nM | 5.77 |
| CHEMBL361708 | HYMENIALDISINE | IC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL481494 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL519118 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL518466 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL480189 | — | IC50 | > | 10000.0 | nM | - |