Compound Detail
CHEMBL507188
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL507188 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | SIDVKOFTVXLYIV-DAXSKMNVSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
6
Publications
0
Known Names
Molecular Properties
380.2
MW (Da)
1.28
ALogP
5
HBA
4
HBD
112.4
PSA (Ų)
0.52
QED
0
Ro5 Violations
0
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.85
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 CHEMBL4630 | IC50 | 7.85 | 7.85 | 14.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase Chk1 | IC50 | = | 14.0 | nM | 7.85 | Inhibition of CHK1 | 19111462 |
| Serine/threonine-protein kinase Chk1 | IC50 | = | 14.0 | nM | 7.85 | Inhibition of Chk1 (unknown origin) | 33901899 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 19111462 | 10.1016/j.bmcl.2008.12.001 | Serine/threonine-protein kinase Chk1 | 1 |
| 19111462 | 10.1016/j.bmcl.2008.12.001 | Receptor-type tyrosine-protein kinase FLT3 | 1 |
| 19111462 | 10.1016/j.bmcl.2008.12.001 | Glycogen synthase kinase-3 beta | 1 |
| 19111462 | 10.1016/j.bmcl.2008.12.001 | NUAK family SNF1-like kinase 1 | 1 |
| 19111462 | 10.1016/j.bmcl.2008.12.001 | Serine/threonine-protein kinase SIK1 | 1 |
| 33901899 | 10.1016/j.ejmech.2021.113445 | Serine/threonine-protein kinase Chk1 | 1 |
Data from ChEMBL 36 via Core Engine