Compound Detail
CHEMBL48283
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Basic Information
| ChEMBL ID | CHEMBL48283 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | FHLKKLFFTNPJKR-UHFFFAOYSA-N |
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
361.5
MW (Da)
6.37
ALogP
3
HBA
1
HBD
30.5
PSA (Ų)
0.64
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 2 meas. best 7.38
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Glucocorticoid receptor CHEMBL2034 | IC50 | 7.38 | 7.28 | 42.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Glucocorticoid receptor | IC50 | = | 42.0 | nM | 7.38 | Inhibition of transcriptional repression in CV-1 cells expressing glucocorticoid... | 15026058 |
| Glucocorticoid receptor | IC50 | = | 66.0 | nM | 7.18 | Inhibition of transcriptional activation in CV-1 cells expressing glucocorticoid... | 15026058 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 15026058 | 10.1016/j.bmcl.2004.01.044 | Glucocorticoid receptor | 5 |
| 15026058 | 10.1016/j.bmcl.2004.01.044 | Progesterone receptor | 1 |
Data from ChEMBL 36 via Core Engine