Compound Detail
CHEMBL483019
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Basic Information
| ChEMBL ID | CHEMBL483019 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XHTXFNBZNWDFBM-SECBINFHSA-N |
1
Targets
2
Activities
2
Assay Types
0
PK Parameters
4
Publications
0
Known Names
Molecular Properties
241.2
MW (Da)
2.94
ALogP
3
HBA
0
HBD
83.7
PSA (Ų)
0.47
QED
0
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
EC50 1 meas. best 4.96
Kd 1 meas.
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 CHEMBL1962 | EC50 | 4.96 | 4.96 | 11000.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Gamma-aminobutyric acid receptor subunit alpha-1 | EC50 | = | 11000.0 | nM | 4.96 | Activity at human GABAA alpha-1-beta-2-gamma-2s receptor expressed in HEK293 cel... | 17311911 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 17311911 | 10.1074/jbc.m700479200 | Gamma-aminobutyric acid receptor subunit alpha-1 | 3 |
| 17311911 | 10.1074/jbc.m700479200 | Rattus norvegicus | 1 |
| 17311911 | 10.1074/jbc.m700479200 | GABA-A receptor; alpha-1/beta-2/gamma-2 | 1 |
| 17311911 | 10.1074/jbc.m700479200 | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine