Compound Detail
CHEMBL4848977
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Basic Information
| ChEMBL ID | CHEMBL4848977 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | VTGRCTLDECIRKA-UHFFFAOYSA-N |
1
Targets
5
Activities
1
Assay Types
0
PK Parameters
0
Publications
0
Known Names
Molecular Properties
322.1
MW (Da)
4.14
ALogP
3
HBA
1
HBD
70.3
PSA (Ų)
0.92
QED
0
Ro5 Violations
4
Rot. Bonds
Drug Information
| Molecule Type | Unknown |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 5 meas. best 8.22
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Mas-related G-protein coupled receptor member X4 CHEMBL4523430 | IC50 | 8.22 | 7.93 | 6.0 | 5 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Mas-related G-protein coupled receptor member X4 | IC50 | = | 6.0 | nM | 8.22 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark fo... | - |
| Mas-related G-protein coupled receptor member X4 | IC50 | = | 6.0 | nM | 8.22 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark fo... | - |
| Mas-related G-protein coupled receptor member X4 | IC50 | = | 10.0 | nM | 8.0 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark fo... | - |
| Mas-related G-protein coupled receptor member X4 | IC50 | = | 23.0 | nM | 7.64 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark fo... | - |
| Mas-related G-protein coupled receptor member X4 | IC50 | = | 27.0 | nM | 7.57 | Antagonist activity at human MRGPRX4 expressed in HEK cells incubated in dark fo... | - |
Data from ChEMBL 36 via Core Engine