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Target Snapshot

CHEMBL4523430 Target Snapshot

Mas-related G-protein coupled receptor member X4 · SINGLE PROTEIN · Homo sapiens

316Compounds
15Assays
0Approved Drugs
402.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q96LA9. Use UniProt Q96LA9 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q96LA9 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mas-related G-protein coupled receptor member X4 as ChEMBL target CHEMBL4523430, mapped to UniProt Q96LA9. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mas-related G-protein coupled receptor member X4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4523430
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q96LA9
Mas-related G-protein coupled receptor member X4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mas-related G-protein coupled receptor member X4 is the right protein anchor across sources, using UniProt Q96LA9 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMas-related G-protein coupled receptor member X4
UniProt AccessionQ96LA9
Component TypeProtein
Sequence Length322 aa

Mas-related G-protein coupled receptor member X4

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mas-related G-protein coupled receptor member X4, mapped to UniProt Q96LA9. Sequence length is 322 aa.

Mapped IDQ96LA9
Review nameMas-related G-protein coupled receptor member X4
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC50402.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4878726 8.52 IC50 3.0 Preclinical
CHEMBL4850889 8.3 IC50 5.0 Preclinical
CHEMBL4874540 8.3 IC50 5.0 Preclinical
CHEMBL4848977 8.22 IC50 6.0 Preclinical
CHEMBL4855031 8.22 IC50 6.0 Preclinical
CHEMBL4858820 8.15 IC50 7.0 Preclinical
CHEMBL4867400 8.15 IC50 7.0 Preclinical
CHEMBL4871722 8.05 IC50 9.0 Preclinical
CHEMBL4852609 7.92 IC50 12.0 Preclinical
CHEMBL4875180 7.82 IC50 15.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
102
6.0
5
6.5
99
7.0
47
7.5
21
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

15
Total Assays
203
Tested Compounds
2
Assay Types
Functional — 13 assays, 203 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 203 6.9
Binding — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine