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Compound Detail

CHEMBL4850568

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Cc1ccc(C(C)C)cc1OCCn1c([N+](=O)[O-])cnc1C

Basic Information

ChEMBL ID CHEMBL4850568
Phase Preclinical
Structure Type MOL
InChI Key HCVHAEUMOBAINC-UHFFFAOYSA-N
1
Targets
2
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names

Molecular Properties

303.4
MW (Da)
3.61
ALogP
5
HBA
0
HBD
70.2
PSA (Ų)
0.60
QED
0
Ro5 Violations
6
Rot. Bonds

Drug Information

Molecule Type Unknown
Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C16H21N3O3
MW 303.36
Aromatic Rings 2
Heavy Atoms 22
NP-Likeness -1.50

Activity Summary

IC50 2 meas. best 5.96

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
Helicobacter pylori
CHEMBL612600
IC50 5.96 5.96 1100.0 1

Activity Data Samples

Top measurements by pChEMBL value

Target Type Rel. Value Units pChEMBL Assay PubMed
Helicobacter pylori IC50 = 1100.0 nM 5.96 Antibacterial activity against Helicobacter pylori P12 incubated for 48 hrs by M... 33234343

Literature References

PubMed DOI Target Context # Activities
33234343 10.1016/j.ejmech.2020.112994 Helicobacter pylori 2
33234343 10.1016/j.ejmech.2020.112994 Clostridium perfringens 1
38830427 10.1016/j.bmcl.2024.129826 Clostridium perfringens 1

Data from ChEMBL 36 via Core Engine